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# Marbrofloxacin injection

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Description

### Marbofloxacin Injection 10%

Composition:

Each ml contains:

Marbofloxacin………………………100mg

Excipients ad………………………….1ml

Description:

Marbofloxacin is a synthetic, bactericidal antimicrobial, belonging to the fluoroquinolone

group, which acts by inhibition of DNA gyrase. It is effective in vitro against a wide range of Gram positive bacteria in particular Staphylococcus and Gram negative bacteria (Escherichia coli, Pasteurella sp) as well as Mycoplasma (Mycoplasma bovis).

Resistance to Streptococcus may occur.

Indications:

In cattle

Treatment of respiratory infections caused by sensitive strains of Pasteurella multocida,

Mannheimia (Pasteurella) haemolytica and Mycoplasma bovis. Treatment of acute mastitis caused by E. coli strains sensitive to marbofloxacin during the lactation period.

In sows

Treatment of metritis mastitis agalactia syndrome caused by bacterial strains sensitive to marbofloxacin.

Administration and Dosage:

Cattle:

Respiratory infections:Intramuscular use.

The recommended dosage is 8 mg / kg body weight i.e. 2 ml / 25 kg body weight in a single injection. If the volume to be injected is more than 20 ml, it should be divided between 2 or more injection sites.

Acute mastitis:Intramuscular or subcutaneous use.

The recommended dosage is 2 mg / kg / day (1 ml / 50 kg) in a single daily injection.

Treatment duration is 3 to 5 days.

The first injection may also be given by the intravenous route too. The subcutaneous route is recommended in heavy cattle.

Sows:

Acute mastitis:Intramuscular use.

The recommended dosage is 2 mg / kg / day (1 ml / 50 kg) in a single daily injection. Treatment duration is 3 days.Side Effects:

Administration by the intramuscular route may cause transient local reactions such as pain and swelling at the injection site and inflammatory lesions which persist at least 12 days after injection.

However, in cattle, subcutaneous route was shown to be better tolerated locally than

intramuscular route. Therefore, the subcutaneous route is recommended in heavy cattle. For the injections, the neck should be preferred in cattle and pigs.

No other undesirable effects have been observed in cattle and pigs.

Contraindications:

Bacterial infections with resistance to other fluoroquinolones (cross resistance).

Do not administer to an animal previously found to be hypersensitive to marbofloxacin or other quinolone.

Withdrawal Time:

Cattle:

Respiratory infections (intramuscular use, 8 mg/kg single dose).

Meat and offal: 3 days.

Milk: 72 hours.

Acute mastitis (intramuscular or subcutaneous use, 2 mg/kg single daily injection for 3 to 5 days).

Meat and offal: 6 days.

Milk: 36 hours.

Sows:

Intramuscular use.

Meat and offal: 4 days.

Storage:

Store below 25ºC, in a cool and dry place, and protect from light.

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